Does garlic really have any benefit? like really? I've seen one pet get sick from slamming the costco sized bag of crispy onion salad topper, two from someone sprinkling more and more garlic/onion powder on the dog's food every day for a while because they're still seeing fleas and ticks, hell I've seen someone stick garlic cloves in a cat's ears to try to clear mites... there's just no telling how creative people can get with garlic, but the one thing I haven't seen yet is garlic actually fixing the problem, I've never seen it actually work.
Therefore, I think it's unwise to recommend giving garlic to a dog as a preventive measure for ticks and fleas over the internet. It's not an effective way of achieving your goal compared to regular removal and/or more appropriate products that are available, it actually is well documented that it can be harmful, and there's no telling how people will use the advise. The toxicity is often overstated, but that doesn't mean it doesn't happen. That article talks about fresh garlic doses, but omits that if you dehydrate and/or powder the garlic you're increasing the concentration of problematic compounds, and It's also rather vague about chronic exposure, which is a thing.
I'm not sure how LD50 came into the discussion, it's not in the article at all. My 2 cents, which nobody asked for, It's a very superficial way of assessing toxicity, it's a statistical measure that tells you at said dose half your test subjects should be dead. What it doesn't tell you is what's an effective therapeutic dose, what dose do ill effects start to happen, what frequency to expect those ill effects at said therapeutic dose, or anything about chronic exposures. LD50 has very little clinical value, It's really not a useful stat point to consider for this type of discussion if you think about it. If you can properly measure the dose, and your product is effective well below any dose that will make you sick, what does the LD50 matter?
As for pharmaceutical products available, Their toxicity is often as exaggerated as garlic's. I'm with @egoldstein. Their safety and efficacy is pretty well documented, They've been on the market for a while with very rare significant complications being reported. If you're in a heavily infested area at risk of tick-born diseases, they will offer more safety then garlic.
Therefore, I think it's unwise to recommend giving garlic to a dog as a preventive measure for ticks and fleas over the internet. It's not an effective way of achieving your goal compared to regular removal and/or more appropriate products that are available, it actually is well documented that it can be harmful, and there's no telling how people will use the advise. The toxicity is often overstated, but that doesn't mean it doesn't happen. That article talks about fresh garlic doses, but omits that if you dehydrate and/or powder the garlic you're increasing the concentration of problematic compounds, and It's also rather vague about chronic exposure, which is a thing.
I'm not sure how LD50 came into the discussion, it's not in the article at all. My 2 cents, which nobody asked for, It's a very superficial way of assessing toxicity, it's a statistical measure that tells you at said dose half your test subjects should be dead. What it doesn't tell you is what's an effective therapeutic dose, what dose do ill effects start to happen, what frequency to expect those ill effects at said therapeutic dose, or anything about chronic exposures. LD50 has very little clinical value, It's really not a useful stat point to consider for this type of discussion if you think about it. If you can properly measure the dose, and your product is effective well below any dose that will make you sick, what does the LD50 matter?
As for pharmaceutical products available, Their toxicity is often as exaggerated as garlic's. I'm with @egoldstein. Their safety and efficacy is pretty well documented, They've been on the market for a while with very rare significant complications being reported. If you're in a heavily infested area at risk of tick-born diseases, they will offer more safety then garlic.