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I can't agree in terms of XL breeds, unfortunately. Medium sized breeds up to around 85-90% of the size of a wolf (which is considerably lighter and smaller than some of the giant XL breeds, actually) are quite healthy and long-living. While giant breeds can be called lucky to reach a two-digit age at all..
Not to talk about the immense amount of food needed, the problems with ecological transportation (as example bicycle, even more with 2 to 3 dogs..), the problems with carrying it if something happened or the dog gets older.
Medium sized dogs can use a backpack carrier, I have such a thing, it's expensive but works very comfortable even at around 90 mph on a motorbike! Dog is on the back and has protective glasses against the wind. Nobody wants to have a dog with over 100 pounds on the back, really. That works for a very short amount of time but even with the best equipment, I wouldn't want to bear with this mass walking or bicycling.
But the main reason is their age span. They're basically failures of evolution, as the size and weight of a wolf is quite the optimum between their limited anti-cancer working defense mechanisms in the body (compared to an elephant, even humans have two different ways of cell-recognition and killing
less, else elephants would die from cancer just due their plain cell amount and failure rate after not even two to three years) and the stamina / strength.
But even a wolf is sub-par in terms of food energy efficiency and body weight to power ratio output over long times compared to as example a Siberian Husky or Alaskan Malamute. A wolf needs to eat around 1,4 to 1,7 times as much energetic resources to maintain the same long-term energetic output.
Still, for me the health and lifespan disadvantage of too big breeds is a no-go. Even with medium sized long living breeds it's always torturing and killing a part of me if a dog's lifespan ends.
Wouldn't want to experience this all four to seven years, really. Even humans out of my family dying don't destroy me that much, actually.