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Change one letter ONLY,

You're not alone, that was a DIFFICULT one! ?
Pred (Prednisone)

Agreed, that's why I, as a non native speaker didn't even want to touch that one. Couldn't find anything either. :D


I'm pretty certain you aren't supposed to tack on additional letters, going by the fact that this game started as a four letter word and after 1247 pages still is a four letter word.

Skipping it and following up from "Drug":

Drum
 
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