Bud, booze, acid, shrooms, Salvia, cigars. I call that my good time safety zone. With moderation and common sense all pretty harmless.
Crack, Opium, DMT. Drugs I want to try. Try being the key word, I want to experience, not ruin my life.
Meth, Heroin, Synthetics, cigarettes or pills. Danger zone, Avoid, This shit will ruin your life or make you the worst president ever!
Grass (and derivatives like hash, etc) - definitely OK. Tried and true, impossible to OD on without taking idiotically over-the-top steps in a deliberate attempt, never heard any BELIEVABLE tales of any sort of horrors, never experienced any worse effects than a screaming case of the munchies and a "morning after droopiness" that doesn't get anywhere near as bad as even a mild beer/booze hangover. And as an extra bonus, it's good for stiff joints and sore muscles (which any actual farm-type can tell you is pretty much "just part of living the farm life")
Acid - Not anymore. Had some good trips, had some bad. Woke up after all of them feeling like I'd been pounded flat, turned inside out, left out in the sun for a day or three, then turned back to right side out and filled with sand. Fun for the moment but not worth the after-effects. (Never mind that nearly all so-called acid these days is nothing more than some speed, usually meth, and something to give you muscle spasms so you think you got the real thing. The vast majority of what gets sold as "acid" these days doesn't even have a nodding acquaintance with honest LSD, forget actually containing any)
Shrooms - Always been "meh" for me. "Acid in small" is the kindest way for me to put it.
Crack or any of the other cocaine variants: Why bother? (Best I ever got from any of them was a numb, runny nose)
Opium - I'm torn... There's absolutely NOTHING I've ever bumped into in the "better living through chemistry" category that *TASTES* nearly as good as crumbling a *TINY* bit - just enough to add the flavor - of opium into a joint. YumYumYumYumYUM! TASTY!!!! But as far as the actual effects? My opinion can be summed up as "<shrug> Big fat hairy deal".
Ritalin - Stay away! Stay far, far far away! Then run further! Then when you can't run any further, steal the first car you can find and drive further than that! When it runs out of gas, grab a horse and ride until it drops, then crawl as far as you can! That shit is pure misery looking for a place to happen! I didn't find out (and did it the hard way) that Ritalin is ranked right alongside heroin, coke, and nicotine for withdrawal nasties until I was past the sweats, puking, shaking, muscle spasms, and drizzling shits (and those are just the "nice" parts) when my supplier stopped coming around. Take it from someone who's been there, done that, and wishes he could find someplace to return the T-shirt: Kicking a Ritalin monkey is absolute screaming misery! Avoid at all costs!
Meth - Years and years ago, me and a chemistry major buddy of mine cooked up two batches. Did it right, too - mass spectrometry (he had access to the college's unit) told us that we'd cooked up better than 93% purity of the real deal in both batches. We both tried some. I wasn't particularly impressed. Neither was he. We sold the first batch to make our money back (and a bit...) and tried a second batch. Got rave reviews on the first one. Tried the second batch. Weren't impressed. Sold it. Spent the next year trying to shake off the guy we sold it to who wanted "more of that stuff - it was incredibly great! All my customers loved it!" before he finally figured out we were serious about not being in the biz anymore. I wouldn't bother with the stuff again if offered.
These days, I'm just a good ol' fashioned pothead, and let the rest pass on by.